Clinical Publications on the use of urea for hyponatremia

Clinical practice guidelines on diagnosis and treatment of hyponatremia.

2014 European Society of Endocrinology, European Society of Intensive Care, European renal Association-EDTA.

Overview of the Treatment of Hyponatremia,
UptoDate, April 6, 2015, Richard Sterns MD, Michael Emmett MD, Josh Forman MD, MSc

Coussement J. Treatment of the Syndrome of Inappropriate Secretion of Antidiuretic Hormone with Urea in Critically Ill Patients. American Journal of Nephrology 2012 35, 265-270

Soupart A. Efficacy and Tolerance of Urea Compared with Vaptans for Long-Term Treatment of Patients with SIADH. C-JASN 2012 7, 742-747

Sterns R. Treatment of hyponatremia: Syndrome of inappropriate antidiuretic hormone secretion and reset osmostat. Up to Date 2013

Decaux G. Urea for long-term treatment of syndrome of inappropriate secretion of antidiuretic hormone. British Medical Journal, 1981, Volume 283

Decaux G. Treatment of euvolemic hyponatremia in the intensive care unit by urea. Critical Care 2010, 14 R184

Decaux G. 5 year treatment of the Chronic Syndrome of Inappropriate Secretion of ADH with oral Urea. Nephron 1993, 63: 468-470

Gunathilake R. Mild hyponatremia is associated with impaired cognition and fall in community-dwelling older persons. L Am Geriatric Soc. 2013 Oct; 61

Borenstein J. Early Recognition of risk factors for adverse outcomes during hospitalization among Medicare patients: A prospective cohort study. BMC Geriatrics. 2013 July 8 13:72

Deitelzweig S. Health Care utilization, costs and readmission rates associated with hyponatremia. Hospital Practice 2013 Feb;41